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. 2019 Jun 20;8:908. [Version 1] doi: 10.12688/f1000research.19592.1

Figure 5. Constrained fuzzy logic simulation results for complex “pSTAT-dimers” in pathway “Signaling by SCF-KIT” from 4 simulations.

Figure 5.

Panel A: Simulations conducted with the default setup provided by ReactomeFIVIz. Logic fuzzy values for two simulations, reference_1 and sorafenib_1, are almost the same except bottom values starting from step 18: 0.0 for reference_1 and 0.0024 for sorafenib_1 (see the insert for an example). Panel B: Same as in Panel A except the initial value of PRKCA was reduced from 1.0 to 0.5. Logic fuzzy values prior to time step 18 are the same for both reference and sorafenib simulations. The results were exported from ReactomeFIViz and plotted in Microsoft Excel.