Figure 7. Functional interaction network for frequently mutated genes in TCGA ovarian cancer samples.

Only part of the FI network was shown here for drugs targeting protein products of genes in the network. Network nodes are genes mutated in at least 5 TCGA samples, where size of the node indicates the number of samples with the mutated gene. Black edges are FIs between genes, blue edges drug-target interactions with <= 100 nM supporting assay values, dashed edges predicted FIs, solid edges extracted from annotated FIs, -> activation or catalysis FIs, -| inhibition FI, - FIs extracted from complexes or inputs of reactions. EGFR, TNIK, PAK3 and sunitinib malate are highlighted in yellow.