Figure 4.

Summary of findings. (A) Eight GABA neuron transcripts were rank-ordered by the magnitude of change in schizophrenia of their expression levels in each of the four cortical regions of the visuospatial WM network. Note that the rank orders are remarkably similar across the four regions; the only exception is the reversal of GAD67 and VIP mRNAs in DLPFC. V1, primary visual cortex; V2, association visual cortex; PPC, posterior parietal cortex; DLPFC, dorsolateral prefrontal cortex. (B) PV-, SST- and VIP-positive subsets of GABA neurons are schematically presented in green, red, and dark blue, respectively (left). Broken lines connect each GABA neuron subset and selectively expressed transcripts (middle). For each transcript, the effect of schizophrenia on its expression level across the WM network is indicated by arrows (right). † indicates significant diagnosis effect, § indicates significant diagnosis-by-region interaction effect.