Table 1.
Average correlation coefficients between inter-regional profiles of cell-specific gene expression and inter-regional profiles of MTR
| Cell (number of cell-specific genes) | Average r (FDR-corrected P-value) | |||||
|---|---|---|---|---|---|---|
| MTR profiles | ΔMTR/year profiles | |||||
| Male | Female | Male | Female | |||
| Visit 1 | Visit 2 | Visit 1 | Visit 2 | |||
| Astrocyte (54) | 0.082 (0.06) | 0.067 (0.07) | 0.079 (0.05) | 0.070 (0.06) | −0.035 (0.75) | 0.08 (0.32) |
| CA1 pyramidal (103) | 0.143 (0.00089)* | 0.131 (0.00089)* | 0.134 (0.00089)* | 0.119 (0.00089)* | 0.024 (0.75) | 0.034 (0.99) |
| Endothelial (57) | −0.053 (0.18) | −0.046 (0.26) | −0.048 (0.22) | −0.022 (0.56) | −0.007 (0.86) | 0.065 (0.59) |
| Ependymal (84) | 0.083 (0.01035)* | 0.072 (0.01259)* | 0.079 (0.01395)* | 0.078 (0.00539)* | −0.017 (0.75) | 0.05 (0.69) |
| Interneuron (100) | 0.026 (0.41) | 0.027 (0.33) | 0.024 (0.42) | 0.024 (0.53) | 0.027 (0.75) | 0.014 (0.98) |
| Microglia (48) | −0.003 (0.94) | 0.00 (0.99) | −0.012 (0.73) | −0.002 (0.96) | −0.016 (0.75) | 0.059 (0.58) |
| Mural (25) | 0.026 (0.69) | 0.030 (0.55) | 0.025 (0.69) | 0.039 (0.52) | 0.02 (0.75) | 0.062 (0.58) |
| Oligodendrocyte (60) | −0.073 (0.06) | −0.032 (0.34) | −0.066 (0.09) | −0.014 (0.71) | 0.095 (0.00045)* | 0.127 (0.00269)* |
| S1 pyramidal (73) | −0.064 (0.06) | −0.033 (0.34) | −0.057 (0.09) | −0.034 (0.46) | 0.093 (0.00045)* | 0.027 (0.99) |
Average correlation coefficients obtained by correlating (across the 34 regions) inter-regional profiles of expression of genes specific to 9 cell-types with inter-regional profiles of average MTR at Visits 1 and 2, and with inter-regional profiles of ΔMTR/year in both sexes. False-discovery rate (FDR) corrected P-values are in brackets. *FDR-adjusted P-value < 0.05.