Table 1.
Participant demographics and neuropsychological testing results
| Subject, Sex | Age at MRI scan NP testing (y:m) | IQ classification FSIQ, SS (%ile) | Language (%ile) | Adaptive functioning (%ile) | ASD diagnosis | Emotional or behavioral concerns | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | Expressive | Receptive | INT | EXT | ATT | OCP | SOM | |||||
| Pediatric Subjects | ||||||||||||
| 1, Mb |
|
ID (1%-37%) | — | 106^ (66%) | — | (3%) | Non-ASD (symptoms present) | N | N | N | — | — |
| 2, F |
|
Low avg 84 (14%) | — | — | — | — | Non-ASD | N | N | N | — | N |
| 3, F |
|
Low avg 81 (10%) | Mod-severe (0.5 %) | 6% | <0.1% | Ex low (1%) | ASD | N | Y | Y | N | N |
| 4, M |
|
Ex low, mild ID 51 (0.05%) | Mod-severe (0.5%) | 2% | 0.3% | Ex low (0.1%) | ASD (Asperger) | Y | N | Y | Y | Y |
| Adult Subjects | ||||||||||||
| 5, M |
|
Ex low 66 (1%) | Mod-severe (1%) | 2% | 3% | — | ASD | Y | N | Y | — | — |
| 6, M |
|
Ex low, mild ID 59 (0.3%) | Below age expectations | Ex low (<1%) | ASD | Y | Y | Y | — | Y | ||
| 7, Mc | 26:4a | — | — | — | — | — | Non-ASD (symptoms present) | N | N | N | Y | N |
Note: — = data not available; M = male; F = female; y = year; m = month; ASD = autism spectrum disorder; ID = intellectual disability; FSIQ = Full Scale Intelligence Quotient; SS = standard score; % = percentile; avg = average; Mod = moderate; Ex = extremely; INT = internalization; EXT = externalization; ATT = attention deficit/hyperactivity problems; OCP = obsessive–compulsive problems; SOM = somatic problems; Y = yes; N = no. aTested specifically for this study. bSubject 1 FSIQ was not available because of significant variability in intellectual profile ranging from the extremely low to average range, in part due to visual limitations. Subscales scores: verbal comprehension = 95 (37th percentile; Average); visual spatial = 86 (18th percentile; low average); fluid reasoning = 64 (first percentile; extremely low); working memory = 67 (first percentile; extremely low); processing speed = 66 (first percentile; extremely low). cNeuropsychological testing was not completed because subject 7 did not speak English. ^based on expressive one-word picture vocabulary (EVT, fourth edition), not a more comprehensive measure of expressive language abilities.