Table 2.

Statistical results for the group comparisons of whole brain, cortical gray matter, white matter, and CC volumes (mm³), cortical thickness (mm), and cortical surface area (mm²) in pediatric and adult groups

	Control	TUBB3 E410K		P
Pediatric
Whole brain	1 196 374.0 (115 682.5)	1 071 493.5 (147 653.2)	–	0.188
		[1 025 473, 957 321, 10 148 051 288 375]
Cortical gray matter	577 592.9 (60 720.8)	550 616.9 (72 825.1)	–	0.374
		[538 023.3, 483 411.5, 527 068.1, 653 964.7]
Cortical thickness	2.982 (0.282)	3.152 (0.120)	–	0.374
		[3.074, 3.025, 3.264, 3.244]
Cortical surface area	167 393.0 (21 037.6)	146 488.0 (17 087.4)	–	0.188
		[146 464.6, 133 014.3, 135 869.0, 170 605.4]
White matter	395 339.9 (58 145.2)	338 966.8 (65 491.6)	–	0.304
		[314 667.4, 291 328.6, 314 025.5, 435 845.8]
CC	3025.6 (473.5)	1 576.2 (240.7)	$\downarrow$	0.002*
		[1933.3, 1496.0, 1409.6, 1465.9]
Deep gray matter	49 637.4 (5565.8)	42 818.8 (4429.5)	–	0.036
		[42 960.4, 38 209.4, 41 337.1, 48 768.5]
Adult
Whole brain	1 304 293.5 (70 474.8)	1 034 269.3 (151 287.8)	$\downarrow$	0.004*
		[1 171 447, 8 720 071 059 354]
Cortical gray matter	602 590.6 (31 327.9)	499 428.3 (81 908.6)	$\downarrow$	0.018*
		[575 754.4, 412 894.2, 509 636.2]
Cortical thickness	3.169 (0.101)	3.069 (0.195)	–	0.365
		[3.294, 2.940, 2.974]
Cortical surface area	166 048.7 (8617.2)	135 289.7 (14 226.1)	$\downarrow$	0.004*
		[144 862.8, 118 942.5, 142 063.8]
White matter	450 147.5 (32 842.2)	343 225.8 (62 153.8)	$\downarrow$	0.004*
		[390 891.3, 272 927.0, 365 859.1]
CC	3343.2 (315.7)	1 834.4 (224.5)	$\downarrow$	0.004*
		[2081.4, 1779.3, 1642.6]
Deep gray matter	53 923.6 (4012.0)	46 690.6 (5421.6)	–	0.048
		[50 787.2, 40 542.7, 48 742.0]

Data: mean (standard deviation).

Data in []: individual values for all subjects (pediatric: [subjects 1, 2, 3, and 4], adult: [subjects 5, 6, and 7]).

*Corrected P < 0.05.