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. 2019 Jul 22;2019(7):CD004080. doi: 10.1002/14651858.CD004080.pub4

Dag 2011.

Methods Randomised controlled trial
Study conducted August 2007 to September 2009
Participants 199 participants: intervention (n = 99), control (n = 100)
Elective open colorectal surgery
Route of feeding: oral
Mean age (range): 62 years (35‐85) (intervention group), 61 years (17‐89) (control group)
Sex (M:F) 52:47 (intervention group), 61:39 (control group)
Interventions Intervention group: oral feeding commenced approximately 12 hours after operation with a fluid diet; this was gradually increased to a solid diet as tolerated by the patient.
Control group: fasted until passage of flatus or stool.
Outcomes Wound infection, anastomotic leakage, pneumonia, mortality, LoS.
Notes Country of study: Turkey
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Randomisation was performed according to a computer generated list immediately after surgery by an independent computer consultant.
Allocation concealment (selection bias) Unclear risk No information provided
Blinding of participants (performance bias) All outcomes High risk No reports of attempts to blind participants. Participants are unlikely to be adequately blinded with an intervention of this nature.
Blinding of personnel (performance bias) All outcomes High risk No reports of attempts to blind personnel. Personnel are unlikely to be adequately blinded with an intervention of this nature.
Blinding of outcome assessor (detection bias) ‐ wound infections High risk Blinding of outcome assessor not discussed. Outcome assessor unlikely to be adequately blinded with an intervention of this nature.
Blinding of outcome assessor (detection bias) ‐ intraabdominal abscesses Unclear risk NA‐ not assessed
Blinding of outcome assessor (detection bias) ‐ postoperative complications e.g. acute myocardial infarction, thrombosis or pneumonia High risk (Pneumonia, toxic hepatitis, sepsis, evisceration, cerebral infarct) Blinding of outcome assessor not discussed. Outcome assessor unlikely to be adequately blinded with an intervention of this nature.
Blinding of outcome assessor (detection bias) ‐ anastomotic leakage/dehiscence High risk Blinding of outcome assessor not discussed. Outcome assessor unlikely to be adequately blinded with an intervention of this nature.
Blinding of outcome assessor (detection bias) ‐ mortality Low risk Blinding of outcome assessor not discussed. Outcome assessor unlikely to affect this outcome.
Blinding of outcome assessor (detection bias) ‐ adverse events (e.g. nausea, vomiting, abdominal distention, aspiration, tube blockage and any other adverse events Unclear risk NA‐ not assessed
Blinding of outcome assessor (detection bias) ‐ length of hospital stay High risk Blinding of outcome assessor not discussed. Outcome assessor unlikely to be adequately blinded with an intervention of this nature.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Dropouts after randomisation not reported.
Selective reporting (reporting bias) Unclear risk No protocol available. All outcomes listed in methods were reported in the results.