Table 2. IC50 Values of Selected Furanochalcones in a Panel of CYP Enzymes in Sacchrosomes.
| IC50 in μM (Sacchrosomes)a |
||||
|---|---|---|---|---|
| entry | 1A1 | 1A2 | 1B1 | 2A6, 2B6, 2C8, 2C9, 2C18, 2C19, 2D6, 2E1, 3A4 |
| 3e | 0.32 ± 0.04 | >10 | >10 | >20 |
| 3g | 0.34 ± 0.03 | 0.17 ± 0.02 | 0.66 ± 0.04 | >20 |
| 3p | 0.30 ± 0.05 | >20 | >20 | >20 |
| 3r | 0.28 ± 0.03 | 4.2 ± 0.8 | 0.78 ± 0.04 | >20 |
The IC50 values represent average (±SD) of results obtained from three independent experiments.