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. 2018 Aug 1;3(8):8553–8566. doi: 10.1021/acsomega.8b01088

Table 2. IC50 Values of Selected Furanochalcones in a Panel of CYP Enzymes in Sacchrosomes.

  IC50 in μM (Sacchrosomes)a
entry 1A1 1A2 1B1 2A6, 2B6, 2C8, 2C9, 2C18, 2C19, 2D6, 2E1, 3A4
3e 0.32 ± 0.04 >10 >10 >20
3g 0.34 ± 0.03 0.17 ± 0.02 0.66 ± 0.04 >20
3p 0.30 ± 0.05 >20 >20 >20
3r 0.28 ± 0.03 4.2 ± 0.8 0.78 ± 0.04 >20
a

The IC50 values represent average (±SD) of results obtained from three independent experiments.