Table 3. CG and CCG3 Genes Up- and Downregulated in Response to Subinhibitory Concentration of CIN (32 μg mL–1) and EUG (64 μg mL–1) and EUGa.
| fold expression |
||||||
|---|---|---|---|---|---|---|
| C. glabrata | CCG3 | |||||
| C. glabrata (ORF status) | S. cerevisiae homologue | CIN | EUG | CIN | EUG | description |
| CAGL0M01760g (verified) | CDR1 | –1.4 | 1.84 | –1.13 | 2.4 | ABC multidrug transporter regulated by Pdr1p |
| CAGL0L10714g (uncharacterized) | ERG2 | –1.67 | 1.3 | –1.4 | 2.1 | C-8 sterol isomerase |
| CAGL0F01793g (verified) | ERG3 | –1.4 | 2.7 | –2.12 | 4.2 | C-5 sterol desaturase |
| CAGL0A00429g (uncharacterized) | ERG4 | –3.34 | –1.11 | –2.0 | –1.25 | C-24 sterol reductase |
| CAGL0L12364g (uncharacterized) | ERG10 | 2.3 | 2.0 | 3.4 | 3.7 | acetyl-CoA C-acetyltransferase have role in sterol biosynthesis |
| CAGL0E04334g (verified) | ERG11 | –1.64 | 1.7 | –1.4 | 2.6 | cytochrome P-450 lanosterol 14-alpha-demethylase role in ergosterol synthesis |
| CAGL0F01419g (verified) | AUS1 | –52 | –20.0 | –7.14 | –5.55 | ABC transporter involved in sterol uptake |
| CAGL0M04169g (uncharacterized) | KRE1 | –16.39 | –20.4 | –18.86 | –12.19 | role in cell wall biogenesis and organization |
| CAGL0G01034g (verified) | FKS1 | –50.0 | –7.24 | –25.0 | –4.76 | component of 1,3-beta-glucan synthase |
a
Genes showing a fold expression ≥1.5 were only considered to assess the changes. Fold expression of 1.5–5.0 are considered as moderate expression, and those showing a change ≥5.0 are considered to be significant.