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. 2019 Jul 18;11:6703–6717. doi: 10.2147/CMAR.S203317

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© 2019 Hsiao et al.

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Changes in mitochondrial oxidative phosphorylation (OXPHOS, complex I+II linked, uncoupled complex I+II-linked, coupled complex III, and uncoupled complex III) over time between patients with radiation therapy (N=33) and active surveillance (N=15). ₂⁶pp

Notes: X-axis indicates time points and Y-axis represents cell respiration rate (pmol O₂/sec/106 cells). A: OXPHOS-complex I+II linked oxidation was measured as ADP-stimulated respiration with malate, pyruvate, glutamate, and succinate as substrates, reflecting the convergence of complex I and II. B: Uncoupled complex I+II was obtained with addition of the uncoupler, FCCP representing maximal oxidative capacity. C: Coupled complex III rate was measured as the ADP-stimulated respiration with DHQ, a substrate for complex III. D: Uncoupled complex III was determined after the addition of the uncoupler, FCCP. ^aRefers to a significant difference compared to day 0 time point of the same group. ^bRefers to a significant difference compared to the AS group at the same time point. *P<0.05; **P<0.01. ^a*b*Represents a significant change in fatigue score (P<0.05) in patients receiving XRT and a significant difference in fatigue score (P<0.05) between XRT and AS groups.

Abbreviations: OXPHOS, oxidative phosphorylation; XRT, external beam radiation therapy; AS, active surveillance; FCCP, carbonylcyanide-p-trifluoromethoxyphenylhydrazone; DHQ, duroquinol.