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(A) Location of introduced mutations S38 (yellow), S168 (orange), F605 (cyan), and control mutation V440 (purple). The substrate, squalene, is indicated in green. S38, S168, and F605 are considered to be in the second sphere of the active site, V440 is outside the active site. (B) A close-up of the active site and the location of the native residues and the substrate.
