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Structure and membrane association of squalene–hopene cyclase from Alicyclobacillus acidocaldarius (PDB entry 1UMP(17)). (A) The prefolded squalene (green, stick) is shown in the active site. The membrane-binding helix is shown in red. (B) The protein inserted into a membrane patch, the substrate is located in the hydrophobic channel (green, stick).
