Figure 3.

(A) Wt (blue) superposed onto the mutated protein variants S38W (yellow), S168F (orange), S168W (red), F605W (cyan), and V440F (purple). The structures used for generation of the figure are averaged structures from the trajectories. Squalene is indicated in green. The membrane patch is not visualized in the following images for clarity, but was included in all simulations. (B) A close-up of the protein backbone structure for the different protein variants in the active site. Squalene is indicated in green.