. 2017 Dec 1;2(12):8600–8609. doi: 10.1021/acsomega.7b01028

Table 2. Optimization of Reaction Conditions^a.

entry	solvent	base	yield (%)^b
1	p-xylene	K₂CO₃	65
2	toluene	K₂CO₃	88
3^c	DMF	K₂CO₃	52
4^d	CH₃CN	K₂CO₃	9
5	toluene	Cs₂CO₃	60
6	toluene	K₃PO₄	55
7	toluene	KF	10
8	toluene	NaHCO₃	82
9^e	toluene	K₂CO₃	0
10	NMP	K₂CO₃	56
11	water	K₂CO₃	5
12	toluene		0
13^f	toluene	K₂CO₃	86
14^g	toluene	K₂CO₃	0

Reaction conditions: 1a (3 mmol), 2a (1 mmol), catalyst (0.25 mol %), base (4 mmol), 16 h, under air and reflux conditions.

Isolated yield.

Reaction conducted at 140 °C.

Reaction conducted at 70 °C.

Reaction conducted at room temperature.

Catalyst used 0.5 mol %.

PCM as the catalyst.

Table 2. Optimization of Reaction Conditionsa.