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. 2019 Jul 16;15:2003–2013. doi: 10.2147/NDT.S215277

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© 2019 Bagyinszky et al.

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3D model of normal PRNP and PRNP with V180I mutation. (A) Val180 (yellow) was predicted to be on hydrophobic contact with Cys214 (orange) on α3 helix. (B) Ile180 (blue) enhanced the contact of α2-α3 helices, since it could form a hydrogen bond with Glu211 (purple) and additional hydrophobic contact with Val210 (green). The orientation of Ile180 was also changed, which could result in a reduced distance between α2–α3 helices.