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. 2019 Jul 17;12:5751–5765. doi: 10.2147/OTT.S208924

Figure 1.

Figure 1

Oridonin inhibits cell proliferation and overcomes gemcitabine resistance in PANC-1/Gem cells. (A) PANC-1/Gem and PANC-1 cells were treated with different doses of gemcitabine for 24 h. The cell viability of the indicated cells was determined using CCK-8 assays. **P<0.01. (B) Cell viability detected by CCK-8 assays in PANC-1/Gem and PANC-1cells treated with different doses of oridonin for 24 h. (C) IC50 values of gemcitabine in PANC-1/Gem and PANC-1 cells. RI=PANC-1/Gem (IC50)/PANC−1 (IC50)=3.68. **P<0.01. (D) Effect of combination treatment with gemcitabine and oridonin using a constant ratio design. CI of gemcitabine and oridonin treatment in PANC-1/Gem cells was analyzed using Calcusyn software. CI=1 indicates additive effect; CI<1 indicates synergistic effect. CI>1 indicates antagonist effect.

Abbreviations: CCK-8, Cell Counting Kit-8; RI, reverse index; CI, combination index; IC50, 50% inhibitory concentration.