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. 2019 Jul 17;12:5751–5765. doi: 10.2147/OTT.S208924

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© 2019 Wang et al.

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Oridonin overcomes PANC-1/Gem cell gemcitabine resistance by suppressing GST pi expression and changing the structure of cytoskeleton. (A and B) Immunofluorescence staining for GST pi and α-tubulin in PANC-1/Gem cells treated with gemcitabine, oridonin or both for 24 h (magnification, x200). (C and D) Western blot analysis of GST pi and α-tubulin in PANC-1/Gem cells treated with gemcitabine, oridonin or both for 24 h. β-actin was used as a loading control. Data were expressed as the mean ± standard deviation. **P<0.01.

Abbreviation: GST, glutathione S-transferase.