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. 2019 Jul 17;12:5751–5765. doi: 10.2147/OTT.S208924

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© 2019 Wang et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Oridonin overcomes PANC-1/Gem cell gemcitabine resistance by inducing cell death. (A and B) PANC-1/Gem cells treated with gemcitabine, oridonin or both for 24 h were analyzed using flow cytometry. Data were expressed as the mean ± standard deviation. **P<0.01. (C) Western blot analysis of Caspase 3, Caspase 9, Bax or Bcl-2 protein expression in PANC-1/Gem cells treated with gemcitabine, oridonin or both for 24 h. β-actin was used as a loading control. (D) Expression of Caspase 3, Caspase 9, Bax or Bcl-2 protein in PANC-1/Gem cells was detected. *P<0.05 and **P<0.01.

Abbreviations: Bcl-2, B-cell lymphoma-2; Bax, Bcl-2-associated x protein.