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. 2019 Jun 6;8:e42832. doi: 10.7554/eLife.42832

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© 2019, Verd et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Appendix 1—figure 6. — (A) Regulatory structure and parameters of the simulated AD/DC circuit. Nodes represent genes and their transcription-factor products. T-bars represent repressive regulatory interactions. All genes are constitutively activated. (B) Sigmoidal regulation-expression function used for the simulations (Equation 31). (C) The number of steady states in the connectionist AD/DC circuit, can be one (black curves), or three (coloured curves) depending on the strength of the back reaction.