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. Author manuscript; available in PMC: 2019 Jul 22.
Published in final edited form as: ACS Nano. 2019 May 17;13(6):6383–6395. doi: 10.1021/acsnano.8b06542

Figure 7.

Figure 7.

(A) Representative intratumoral temperature profiles during AMF (420 kHz, 26.9 kA/m) exposure of mice injected with a single dose of 5% dextrose (AMF), CoMn-IONP nanoclusters (6 mg Fe/kg) and IONP nanoclusters (6 mg Fe/kg). The navy curve shows the intratumoral temperature during the 4th cycle in a mouse that was treated with CoMn-IONP nanoclusters (6 mg Fe/kg) and AMF once a week for 4 weeks. (B) Tumor growth profiles of mice with ES-2 xenografts after 4 cycles of the following treatments: (i) no treatment; (ii) CoMn-IONP + AMF, mice injected with CoMn-IONP nanoclusters (6 mg Fe/kg) and exposed to AMF for 30 min; (iii) IONP + AMF, mice injected i.v. with IONP nanoclusters (6 mg Fe/kg) and exposed to AMF for 30 min; (iv) CoMn-IONP, mice injected i.v. with CoMn-IONP nanoclusters (6 mg Fe/kg); (v) IONP, mice injected with IONP nanoclusters (6 mg Fe/kg); and (vi) AMF, mice injected with 5% dextrose and exposed to AMF. *p < 0.05 when compared with non-treated animals. (C) Tumor growth profiles of mice with ES-2 xenografts after the following treatments: (i) no treatment; (ii) CoMn-IONP + 10 min AMF, mice injected with CoMn-IONP nanoclusters (6 mg Fe/kg) and exposed to AMF for 10 min when intratumoral temperatures reached 42 °C (total exposure time to AMF 30 min) once a week during four weeks (4 cycles); (iii) CoMn-IONP + 40 min AMF, mice injected with CoMn-IONP nanoclusters (6 mg Fe/kg) and exposed once to AMF for 40 min when intratumoral temperatures reached 42 °C (total exposure time AMF 60 min). *p < 0.05 when compared with CoMn-IONP + 10 min AMF.