(A) Changes in body weights of untreated mice and mice treated with 4 cycles of CoMn-IONP nanocluster-mediated hyperthermia. (B-D) Blood levels of biomarkers (alkaline phosphatase (ALP), aminotransferase (ALT), creatine kinase (CK), blood urea nitrogen (BUN) and creatinine (Cr)), blood electrolytes, and proteins in non- and hyperthermia-treated mice.