Table 1.
Characteristics of all patients versus patients stratified by complete revascularization
| All patients (n=50) | Patients achieving complete revascularization (n=32) | Patients not achieving complete revascularization (n=18) | p-value | |
|---|---|---|---|---|
| Age, median [IQR] | 66 [50–74] | 64 [50–74] | 69 [50–78] | 0.944 |
| Women (%) | 34 (68%) | 22 (69%) | 13 (68%) | 0.942 |
| Transferred from outside hospital | 15 (30%) | 12 (38%) | 3 (16%) | 0.107 |
| Baseline NIHSS, median [IQR] | 18 [11–22] | 18 [7–22] | 18 [13–21] | 0.172 |
| IV tPA administered | 40 (80%) | 24 (75%) | 17 (89%) | 0.239 |
| Time Onset to IV tPA (min), median [IQR] | 148 [103–182] | 132 [83–177] | 165 [132–189] | 0.151 |
| Endovascular therapy administered | 25 (50%) | 22 (69%) | 3 (17%) | <0.001 |
| Large vessel occlusion (LVO) location on cerebral angiogram or COW MRA (%) ^ | ||||
| Intracranial ICA | 5 (10%) | 3 (9%) | 2 (12%) | 0.114 |
| MCA: M1 | 32 (65%) | 24 (75%) | 8 (47%) | |
| MCA: M2 or other | 12 (25%) | 5 (16%) | 7 (41%) | |
| Baseline ADC Core lesion (mL), with ADC ≤620 μm2/sec, median [IQR] | 18 [1–53] | 9 [1–43] | 35 [3–96] | 0.115 |
| Baseline ADC intensity value of Core lesion, median [IQR] | 485 [449–518] | 496 [456–524] | 466 [405–506] | 0.041 |
| Baseline Tmax>6 sec volume (mL), median [IQR] | 178 [110–267] | 212 [120–266] | 128 [73–272] | 0.236 |
| Percent of Core with ADC ≤620 μm2/sec at 24-hours, median [IQR] | 48% [14–86] | 33% [8–60] | 92% [62–99] | <0.001 |
| ADC intensity value of Core lesion at 24-hours, median [IQR] | 640 [468–732] | 709 [600–790] | 437 [361–560] | <0.001 |
| Significant core lesion reversal by 24-hours (%) | 26 (52%) | 22 (69%) | 4 (22%) | 0.002 |
| DWI lesion volume (mL) at 24-hours, median [IQR] | 40 [14–134] | 29 [11–66] | 79 [27–184] | 0.102 |
| Early Neurologic Improvement (ENI) at 24-hours (%) | 19/49 (38%) | 17/31 (55%) | 2 (11%) | 0.003 |
| NIHSS at Discharge | 4 [0–13] | 4 [0–10] | 8 [0–26] | 0.074 |
| DWI Lesion Volume at 5 days, median [IQR] | 43 [18–107] | 39 [15–67] | 93 [23–204] | 0.048 |
| Good clinical outcome (GCO), mRS 0–2 at 90 days | 16/35 (46%) | 15/24 (63%) | 1/11 (9%) | 0.003 |
IQR, interquartile range; NIHSS, National Institutes of Health Stroke Scale; ICA, internal carotid artery; MCA, middle cerebral artery; tPA, tissue plasminogen activator; TICI, Thrombolysis in Cerebral Infarction; mRS, modified Rankin Scale
^
Two patients, one from each stratified group, did not have visible large vessel occlusions on cerebral angiogram or COW MRA