Table 1.
Baseline demographic and clinical characteristics
| Study Group |
||
|---|---|---|
| Characteristic | Standard Therapy (N = 35) |
Intrastromal Voriconazole (N = 35) |
| Sex, No. (%) | ||
| Male | 18 (51) | 26 (74) |
| Female | 17 (49) | 9 (26) |
| Age, median (IQR), y | 55 (41, 62) | 53 (42, 60) |
| Occupation, No. (%) | ||
| Agriculture | 15 (47)a | 11 (33)a |
| Non-agriculture | 17 (53)a | 22 (67)a |
| Medication use at enrollment, No. (%) | 23 (68)a | 25 (71) |
| Trauma, No. (%) | ||
| Stick | 3 (9) | 7 (20) |
| Leaf | 1 (3) | 2 (6) |
| Finger | 1 (3) | 0 (0) |
| Dust | 4 (11) | 3 (9) |
| Mud | 4 (11) | 4 (11) |
| Insect | 1 (3) | 5 (14) |
| Other | 9 (26) | 4 (11) |
| Unknown objectb | 2 (6) | 0 (0) |
| None | 10 (29) | 10 (29) |
| Affected eye, No. (%) | ||
| Right | 17 (49) | 15 (43) |
| Left | 18 (51) | 20 (57) |
| Visual acuity, median (IQR) | ||
| LogMAR | 1.7 (1.6, 1.8) | 1.7 (1.6, 1.8) |
| Snellen | HM (CF, LP) | HM (CF, LP) |
| Ulcer location, No. (%) | ||
| Central | 32 (91) | 30 (86) |
| Peripheral | 3 (9) | 5 (14) |
| Infiltrate and/or scar, median (IQR), mmc | 5.1 (4.1, 6.4) | 4.8 (4.0, 5.7) |
| Hypopyon, No. (%) | ||
| No | 13 (37) | 16 (46) |
| <0.5 mm | 7 (20) | 6 (17) |
| >=0.5 mm | 15 (43) | 13 (37) |
| % Depth, No. (%) | ||
| >0–33 | 10 (29) | 13 (37) |
| >33–67 | 16 (46) | 11 (31) |
| >67–100 | 9 (26) | 11 (31) |
| Epithelial defect, median (IQR), mmc | 4.1 (3.5, 5.5) | 4.6 (3.8, 5.3) |
| Duration of symptoms, median (IQR), d | 7 (4, 14) | 7 (5, 15) |
| Systemic disease, No. (%) | 5 (14) | 7 (20) |
a
Missing data
b
Includes chemicals, cow tail, finger nail, hay, iron ro d, red chili powder, sand, spark from fire, sugarcane leaf, and wood
c
Geometric mean
Abbreviations: CF = count fingers, d = days, HM = hand motion, IQR = interquartile range, LogMAR = logarithm of the minimum angle, LP = light perception, mm = millimeters, No. = number, y = years