Table 3:
Univariate and multivariate analysis of exocrine function post pancreaticoduodenectomy (PD) and distal pancreatectomy (DP). (IDDM = insulin-dependent diabetes mellitus, NIDDM = non-insulin dependent diabetes mellitus)
| Univariate | Multivariable | ||
|---|---|---|---|
| P value | P value | HR (95% CI) | |
| Age | 0.0084 | ||
| Gender | 0.52 | ||
| Race (Caucasian vs. Other) | 0.01 | 0.014 | 1.42 (1.07–1.87) |
| Body Mass Index (BMI)† | <.0001 | 0.0003 | 0.97 (0.96–0.99) |
| Tobacco Use (Yes vs. No/In past) | 0.0038 | ||
| Smoker vs. Non-smoker | |||
| Ex-smoker vs. Non-smoker | |||
| Alcohol Abuse (No vs. Yes) | 0.34 | ||
| Family History Diabetes | 0.12 | 0.0072 | |
| Yes vs. No | 1.09 (0.89–1.34) | ||
| Unknown vs. No | 0.80 (0.66–0.98) | ||
|
Tumor Type (Malignant vs. Benign) |
<.0001 | ||
| Pancreatitis | 0.18 | ||
| Steatorrhea | <.0001 | 0.0007 | 1.38 (1.14–1.66) |
| Jaundice | <.0001 | ||
| Weight Loss | <.0001 | ||
| Albumin† | 0.20 | ||
| Bilirubin† | <.0001 | p=0.019 | 1.02 (1.00–1.03) |
| Pre-operative Diabetes | 0.64 | ||
| None vs. Type 2 NIDDM | |||
| Type 1 IDDM vs. Type 2 NIDDM | |||
| Type 2 IDDM vs. Type 2 NIDDM | |||
| Operation (PD vs. DP) | <.0001 | <.0001 | 1.99 (1.53–2.60) |
†
Analyzed as a continuous variables