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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Curr Opin Cell Biol. 2019 Jan 23;58:34–41. doi: 10.1016/j.ceb.2018.12.007

Figure 1. Aurora B-dependent error corrections of aberrant attachments.

Figure 1.

A. Normal (amphitelic) and aberrant (syntelic and merotelic) attachments. B. Aurora B-mediated microtubule dissociation from aberrant attachments. Generation of an unattached kinetochore (yellow) activates the spindle checkpoint. C. Kinetochore attached to lateral side of microtubules can slide by the CENP-E motor toward the spindle equator [55]. Lateral attachment does not silence the checkpoint (yellow) [56*]. D. Conversion of lateral attachment to end on attachment, and stabilization of amphitelic attachments, which silence the spindle checkpoint. Color brightness of each kinetochore indicates the level of Aurora B-dependent phosphorylation (or checkpoint strength).