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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Curr Opin Cell Biol. 2019 Jan 23;58:34–41. doi: 10.1016/j.ceb.2018.12.007

Figure 3. Members of the CPC; Aurora B, INCENP, Survivin and Borealin.

Figure 3.

Aurora B interacts with INCENP at the IN-box domain, which allosterically activates Aurora B. Aurora B-dependent phosphorylation (yellow circles) at the Aurora B activation loop and on INCENP promotes full activation. The N-terminal CEN domain of INCENP interacts with Survivin and Borealin. This trimeric module targets the CPC to centromere-enriched histone phosphorylation marks; H3 phosphorylated at Thr3 recognized by the BIR domain of Survivin, and H2A phosphorylated at Thr120, which recruits Borealin through Sgo1 in a manner dependent on Cdk1-mediated phosphorylation at Borealin (orange circles). The SAH domain interacts with microtubules, while the PRD domain also supports microtubule binding, which is suppressed by Cdk1-dependent phosphorylation (orange circles). INCENP also interacts with HP1, which appears to facilitate substrate recognition.