. Author manuscript; available in PMC: 2020 Feb 1.

Published in final edited form as: Bone Marrow Transplant. 2019 Jan 22;54(8):1337–1345. doi: 10.1038/s41409-019-0438-z

Table 3:

Factors associated with mortality

Multivariable Cox Regression Model for Mortality
	N	HR	95% CI	p-value
Diagnosis/Phase
ALL CR1^*	15	1.0	--	--
ALL CR2/Advanced	106	2.6	(1.4, 4.9)	0.002
AML CR1/MDS	48	2.2	(1.1, 4.3)	0.028
AML CR2/AML Advanced	63	2.9	(1.5, 5.4)	0.001
1^st HCT Preparative Regimen
TBI-based	198	1.8	(1.0, 3.1)	0.052
Chemo-based^*	23	1.0	--	--
RIC	11	4.1	(1.9, 9.1)	<0.001
1^st HCT to relapse (months)
0–6	114	3.2	(2.2, 4.7)	<0.001
>6–12	66	2.1	(1.4, 3.2)	<0.001
>12+	52	1.0	--	--

Reference group

Note: Variables examined for potential inclusion in model were: Sex, Year of HCT, Time from HCT to relapse, Donor type, Diagnosis/Phase at HCT, Conditioning regimen, MRD status at relapse, Time from diagnosis to HCT, Age at HCT, Age at relapse.

Abbreviations: ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; CHEMO, chemotherapy; CI, confidence interval; GVHD, graft-vs-host disease; HCT, hematopoietic cell transplant; HR, hazard ratio; IS, immune suppression; MDS, myelodysplastic syndrome; RIC, reduced intensity conditioning; TBI, total body irradiation.