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. 2019 Jul 22;9:10542. doi: 10.1038/s41598-019-46896-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Collagen abundance in connective tissue. Forest plot for the estimated collagen abundance in IVD, articular cartilage, skeletal muscle, tendon, and adipose tissue. Shown are the effect sizes (black dots) with 95% CI (black lines) for each dataset included in the analysis and the overall effect sizes (ES) with 95% CI (black diamonds) for each tissue type. Y-axis labels indicate the included datasets and study numbers in the format dataset(study) according to Supplemental Table 1, where extended information can be found. The size of the circle is proportional to the number of datasets.