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. 2019 Jul 22;9:10542. doi: 10.1038/s41598-019-46896-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Technical contributors to inter-study differences. Forest plots for the estimated effect size of collagen abundance for different quantification methods (a), and original data transformations (b–e). For a, data are presented as a ratio to the overall estimate. For (b–e), shown are IVD (b,c) and articular cartilage (d,e) subgroup averages and 95% CI as black dots/black lines for different type of transformations (b,d), or adjustment (c,e). The overall effect sizes and 95% CI as black diamonds. The size of the circle is proportional to the number of datasets, *indicates statistical significance.