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. 2019 Jul 22;9:10542. doi: 10.1038/s41598-019-46896-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Estimating the contribution of biological factors to collagen abundance in IVD and articular cartilage. Forest plot for the estimated collagen abundance in IVD (a–c) and articular cartilage (d) as a function of sex (a), age (b), and tissue sub-location (c,d). Shown are subgroup averages and 95% CI as black dots/black lines, the overall effect sizes and 95% CI as black diamond, the number of datasets included within each subgroup is indicated in parenthesis. The size of the circle is proportional to the number of datasets; *indicates statistical significance.