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. 2019 Jul 22;9:10552. doi: 10.1038/s41598-019-47156-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) USF signals acquired at x = 0.00 mm, y = 0.00 mm, in the four phantoms with different Z2 = 6, 9, 12 and 15 mm. In the left plot, it shows the USF signal strength significantly decreased with the increase of Z2. In the right plot it shows the normalized signal strengths over time: the USF signal duration changed slightly when the Z2 increased. (b) Normalized 2D USF images acquired at different imaging depth Z2 = 6, 9, 12 and 15 mm. (c) Relationship between SNR of imaged tube and imaging depth Z2. (d) Relationship between FWHM of imaged tube and imaging depth Z2.