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. 2019 Jul 22;9:10593. doi: 10.1038/s41598-019-47087-7

Figure 2.

Figure 2

Network biology for protein-protein interactions (PPI) and miRNA-Protein interactions constructed with frailty-related genes as seeds. To build the network, we used BisoGenet40 plugin for Cytoscape (v. 3.7). Nodes represent proteins and miRNAs. Orange nodes represent those frailty-related genes (seeds). White nodes represent the first neighbor’s protein of the seeds, and yellow nodes represent miRNAs. Edges (green) represent PPI and miRNA-protein interactions.