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. 2019 Jul 22;10:3257. doi: 10.1038/s41467-019-11136-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Intrinsic size and its phenotypic plasticity are controlled via Wnt and TGF-β signaling. Scheme showing the regulation of intrinsic size and phenotypic plasticity as independent inputs on Wnt signaling. Wnt-dependent axial patterning induces bud initiation via TGF-β signaling, thereby stops the developmental growth phase and determines maximum polyp size. This process can be induced or suppressed using K02288 or LDN-193189, respectively. Cell size regulation is temperature-dependent but independent of Wnt and TGF-β signaling