Fig. 6.

Time-dependent killing assay and the in vivo assay of Compounds 20 and 26. a Time-dependent killing of VRE ATCC 29212 by teixobactin and Compound 20. This assay was done twice to confirm the results (n = 2). Data represent two independent experiments ± s.d. Source data are provided as a Source Data file. b Single dose treatment (i.v., 1 h post infection, six female mice per group) in septicemia protection model using S. pneumoniae D39. Survival was depicted 48 h after infection. ***P < 0.001 (determined by nonparametric log-rank test). Source data are provided as a Source Data file. c BALB/c female mice were infected with bioluminescent S. pneumoniae Xen-10 (A66). At left, two mice were treated with compound 20 (2 mg kg⁻¹) and the right two mice were negative control. After 48 h, four mice were using IVIS Lumina II. d Single dose (i.v., 2 h post infection, three mice per group) treatment with compound 20 and vancomycin in neutropenic mouse thigh infection model using MRSA 33591. For drug-treated animals, thigh colony-forming units (c.f.u.) were determined at 26 h post infection. For controls, c.f.u. in thighs was determined at 0, 2, and 26 h post infection. Source data are provided as a Source Data file. Source data are provided as a Source Data file