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. 2019 Jul 22;9:10588. doi: 10.1038/s41598-019-46745-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PCSK9 function is negatively correlated with the uptake of lipoteichoic acid by hepatocytes. (A) HepG2 hepatocytes were pre-treated with various concentrations of recombinant wildtype PCSK9 two hours before the treatment of the fluorescently labeled LTA (BODIPY-FL-LTA, 1 μg/mL). After 24 hours of LTA treatment, cells were analyzed by flow cytometry. Mean fluorescence intensity were normalized to cells without PCSK9 treatment. (B) Same as experiment as in (A) but HepG2 hepatocytes were treated with 3 different PCSK9 LOF variants, rs11583680, rs11591147 and rs562556. Results are shown as percent change in LTA uptake as compared cells treated with wildtype PCSK9 at the same concentration. Error bars are Standard Deviations; n = 3 experiments per data point.