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. 2019 Jul 22;9:10603. doi: 10.1038/s41598-019-47112-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PV overexpression affects mitochondrial density and position of mitochondria in distal cellular processes. Representative CG4 cells are depicted from IncuCyte images (A,B). Mitochondria were visualized by mitochondria-targeted red fluorescent protein (red) and cellular processes were visualized by Calcein-AM (green). Representative images are shown for C-, GFP- and PV-CG4 cells (C,D). In (D) separate images for cytoplasm (green, upper), mitochondria (red, middle) and merged images (lower) are shown. In addition, average length of processes (E,G) and mitochondrial density in the processes (F,H) was analyzed. Cellular process length of CG4 cells was evaluated by automatically acquired real-time images by the IncuCyte Imaging system. Single cells were analyzed and the length of cellular processes was measured. Average process’ length was evaluated by measuring total length of all processes per cell and dividing this number by the number of processes in the same cell. Error bars represent SEM, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.