Table 4.

Genotype-specific diseases and biofunctions altered in HCV-induced progressive liver injury.

Diseases or Functions Annotation	−log10(p-value)	Genes (n)
HCV genoptype 3 vs HCV genotype 1
colorectal cancer	3.11	30
abdominal cancer	2.78	471
digestive system cancer	2.78	471
metastatic colorectal cancer	2.41	27
neoplasia of epithelial tissue	2.40	455
hepatocellular carcinoma	2.36	454
liver tumor	2.34	455
primary biliary cirrhosis	2.34	6
transport of bile salt	2.06	4
Budd-Chiari syndrome	1.90	6
biliary excretion of cholesterol	1.55	2
proliferation of oval cells	1.55	2
uptake of organic anion	1.55	2
excretion of lipid	1.45	3
HCV genotype 1 vs NDL
cerebrotendinous xanthomatosis	2.47	6
excretion of lipid	2.06	5
progressive intrahepatic cholestasis	2.00	28
damage of liver	1.86	10
progressive familial intrahepatic cholestasis type 1	1.83	27
injury of liver	1.59	9
liver adenoma	1.45	5
HCV genotype 3 vs NDL
metastasis	3.00	47
metastatic colorectal cancer	2.94	46
colorectal cancer	2.77	47
progressive intrahepatic cholestasis	1.86	24
cerebrotendinous xanthomatosis	1.82	5
progressive familial intrahepatic cholestasis type 1	1.67	23
Budd-Chiari syndrome	1.55	8
biliary excretion of lipid	1.48	3
excretion of lipid	1.40	4
damage of liver	1.33	8

−log₁₀(p-value) < 1.30.