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. 2019 Jul 22;9:10601. doi: 10.1038/s41598-019-47000-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Evolution of HCT116 spheroid structure as imaged by OCT. Cross-sectional OCT images showing the growth of the spheroids with day and the presence of necrosis (red arrow) at day 7. Scale bars on OCT images represent 200 μm. (b) Brightfield images of HCT116 spheroids merged with widefield fluorescence imaging of the PI identifying dead cells in the necrotic core. Scale bar on images represent 100 μm.