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. 2019 Jul 22;9:10585. doi: 10.1038/s41598-019-47036-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Modulation of the amplitude dynamics of STN LFP by HF DBS. (A,B) Time courses of the filtered LFP (green curves) and the smoothed order parameter R (blue curves) of STN neurons (1)–(4) stimulated by aDBS with the interphase gaps $G W = 0 ms$ and stimulation intensity (A) $K = 0.5$ and (B) $K = 1.5$ . The values of the order parameter are scaled by the factor 1/25. The stimulation starts at $t = 20 s$ . The red stepwise curve indicates the on- and off-epochs of aDBS. The LFP thresholds for aDBS $T h_{on} = T h_{off} = 0.01$ (upper value of the red stepwise curves). The black dashed lines indicate the 65-percentile of the order parameter time variation starting from $t = 50 s$ . (C,D) Mean and median values of the LFP burst length versus parameter of the stimulation intensity K for cDBS and aDBS as indicated in the legend (BL stands for “burst length”) and for the interphase gap (C) $G W = 0 ms$ and (D) 2 ms. (E–G) Examples of the LFP burst length distribution for cDBS and aDBS illustrated by frequency histograms for two values of K and GW, as indicated in the legends.