Table 6.

Safety for off label prescription of melatonin.

Clinical condition	Melatonin dose	References
Dermal hyperpigmentation	1 g/day p.o. for 1 month	(230)
Parkinson's disease	0.25 and 1.25 mg/kg i.v.	(231)
Amyotrophic lateral sclerosis	60 mg/day p.o. for 13 months	(232)
Amyotrophic lateral sclerosis	300 mg/day, rectal for 2 years	(233)
Muscular dystrophy	70 mg/day for 9 months	(234)
Multiple sclerosis	50–300 mg/day p.o. for 4 years	(235)
Liver surgery	50 mg/kg	(236)
Healthy individuals	80 mg/h for 4 h	(237)
Healthy women	300 mg/day for 4 months	(238)
Dose escalation in healthy individuals	10–100 mg p.o.	(239)
Dose escalation in healthy individuals	10–100 mg p.o.	(240)