Table 2.
Univariate and multivariate survival analyses using the Cox proportional hazard model.
| Characteristics | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | |
| Age | 0.946 | 0.899–0.995 | 0.031 | 0.988 | 0.913–1.069 | 0.760 |
| Gender | ||||||
| Male | Ref | Ref | ||||
| Female | 0.969 | 0.427–2.200 | 0.940 | 1.084 | 0.354–3.321 | 0.887 |
| Race | ||||||
| Chinese | Ref | Ref | ||||
| Non-Chinese | 3.641 | 0.854–15.528 | 0.081 | 3.285 | 0.310–34.771 | 0.323 |
| ECOG Performance Score | ||||||
| 0–1 | Ref | Ref | ||||
| 2 | 0.673 | 0.158–2.877 | 0.594 | 0.977 | 0.201–4.747 | 0.977 |
| PCI score | ||||||
| 0–20 | Ref | Ref | ||||
| 21–39 | 1.918 | 0.639–5.753 | 0.245 | 2.441 | 0.578–10.311 | 0.225 |
| Pathological T stage (8 th Edition) | ||||||
| T1 | Ref | Ref | ||||
| T3 – T4 | 0.751 | 0.099–5.704 | 0.782 | 0.145 | 0.013–1.568 | 0.112 |
| Pathologic N stage (8 th Edition) | ||||||
| N0–N1 | Ref | Ref | ||||
| N2–N3 | 1.762 | 0.783–3.968 | 0.171 | 2.609 | 0.746–9.128 | 0.133 |
| PAXPI1 expression | ||||||
| Low (score 0–3) (n = 24, median OS = 34.6 months) | Ref | — | — | — | ||
| High (score 4–9) (n = 32, median OS = 43.3 months) | 2.595 | 1.022–6.589 | 0.045 | — | — | — |
| SSBP2 expression | ||||||
| Low (score 0–3) (n = 27, median OS = 29.8 months) | Ref | — | — | — | ||
| High (score 4–9) (n = 30, median OS = 42.3 months) | 1.886 | 0.812–4.378 | 0.140 | — | — | — |
| DTYMK expression | ||||||
| Low (score 0–3) (n = 24, median OS = 29.8 months) | Ref | — | — | — | ||
| High (score 4–9) (n = 35, median OS = 40.3 months) | 0.846 | 0.345–2.077 | 0.715 | — | — | — |
| IHC set | ||||||
| 0 or 1 dysregulated markers (n = 41, median OS = 42.3 months) | Ref | Ref | ||||
| 2 dysregulated markers (n = 17, median OS = 18.4 months) | 2.844 | 1.212–6.674 | 0.016 | 5.097 | 1.731–15.007 | 0.003 |
Abbreviations: HR, hazard ratio; ECOG, Eastern Cooperative Oncology Group; PCI, peritoneal carcinomatosis index; CC, completeness of cytoreduction.