Table 2.

Comparison between patients treated with single vs. multiple anti-CD20 infusions at last follow-up.

Parameter	Unit	Single infusion (n = 16)	Multiple infusions (n = 11)	P-value
B-cell subsets below the age-related normal rangea
CD19 positive < 100 cells/μl	N (%)	0 (0)	0 (0)	1.00
Transitional < 0 cells/μl	N (%)	0 (0)	0 (0)	1.00
Mature < 60 cells/μl	N (%)	1 (6)	1 (9)	1.00
Memory < 30 cells/μl	N (%)	13 (81)	7 (64)	0.39
IgM memory < 10 cells/μl	N (%)	9 (56)	4 (36)	0.44
Switched memory < 20 cells/μl	N (%)	13 (81)	8 (73)	0.66
Immunoglobulins below the normal rangeb
IgG < 700 mg/dl	N (%)	5 (31)	6 (54)	0.26
IgG < 160 mg/dl (severe hypogammaglobulinemia)	N (%)	2 (13)	2 (18)	1.00
IgA < 70 mg/dl	N (%)	4 (25)	3 (27)	1.00
IgA < 10 mg/dl (severe IgA deficiency)	N (%)	2 (13)	2 (18)	1.00
IgM < 40 mg/dl	N (%)	0 (0)	1 (0)	0.41
Impaired antigen-specific IgG titerb
Anti-HBV < 10 mIU/ml	N (%)	11 (69)	9 (82)	0.66
Anti-tetanus < 0.1 IU/ml	N (%)	3 (19)	6 (54)	0.09
Anti-tetanus < 0.6 IU/ml	N (%)	15 (94)	9 (82)	0.55
Impaired antigen-specific memory B cells
Anti-HBV < 10 count/106 cells	N (%)	7 (58)c	3 (60)d	1.00
Anti-tetanus < 10 count/106 cells	N (%)	8 (67)c	3 (60)d	1.00

Data were compared by a Fisher's exact test.

^aNormal range indicated in Piatosa et al. (15).

^bRange indicated in the diagnostic laboratory of our Institution.

^cN = 12.

^dN = 5.