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. 2019 Apr 23;8(8):768–774. doi: 10.1002/sctm.18-0247

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© 2019 The Authors. stem cells translational medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Biological properties of normal HSCs and LSCs. Normal HSCs have three major biological features or stem cell properties: self‐renewal, multipotency, and quiescence. After acquiring genetic lesions, HSCs undergo cellular transformation to become LSCs that retain the major stem cell properties of HSCs with enhanced signaling activities and also acquire some unique biological features. These biological features define the cellular states of HSCs and LSCs, and provide opportunities to develop strategies for specifically targeting LSCs while sparing normal HSCs. Abbreviations: HSC, hematopoietic stem cell; LSC, leukemia stem cell.