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. 2019 Apr 23;8(8):844–857. doi: 10.1002/sctm.18-0182

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© 2019 The Authors. stem cells translational medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Mineral formation in calvarial bone defects. (A): von Kossa staining revealing bone formation (arrows) in all the conditions within the defects (delineated by a dotted line), at day 14, and 2 and 3 months. Inset detail at day 14: normoxia (Aa), hypoxic priming (Ab), and FGF‐2 priming (Ac). Scale bars: 50 μm. (B): Quantitative analysis of von Kossa staining showing that mineral formation was significantly increased in FGF‐2 primed samples at all‐time points when compared with control (stem cells from human exfoliated deciduous teeth with no priming) or hypoxic primed samples. At 2 and 3 months, bone formation was also increased in the defects filled with hypoxia primed constructs when compared with control constructs. ****, p < .0001.