Table 2.
Characteristics of the RIHD models at week 1, 3, and 19, respectively.
| Parameter (unit) | Week 1 | Week 3 | Week 19 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Control | RT | p-value | Control | RT | p-value | Control | RT | p-value | |
| Body weight at the endpoint (g) | 270 ± 9 | 254 ± 8 | 0.205 | 394 ± 11# | 366 ± 10# | 0.091 | 597 ± 24# | 425 ± 43#* | 0.004 |
| Heart weight (g) | 1.21 ± 0.07 | 1.13 ± 0.05 | 0.340 | 1.33 ± 0.05 | 1.45 ± 0.09# | 0.286 | 1.74 ± 0.08# | 1.34 ± 0.06#* | 0.002 |
| Lung weight (g) | 1.35 ± 0.06 | 1.64 ± 0.07* | 0.006 | 2.01 ± 0.09# | 2.72 ± 0.25#* | 0.014 | 2.29 ± 0.17# | 2.26 ± 0.18# | 0.883 |
| Heart weight/body weight ratio*1,000 | 4.45 ± 0.13 | 4.44 ± 0.10 | 0.918 | 3.38 ± 0.10# | 3.99 ± 0.32# | 0.100 | 2.92 ± 0.09# | 3.36 ± 0.35# | 0.239 |
Values are mean ± SEM, n = 8,
*
p < 0.05 vs. control, unpaired t-test within the same time points. p-values refer to the unpaired t-test at each time point.
#
p < 0.05 vs. week 1 within the same group (control or RT), One-Way ANOVA, Bonferroni post-hoc test. RT, radiotherapy.