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. 2019 Jul 16;10:391. doi: 10.3389/fendo.2019.00391

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Copyright © 2019 Arendt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The melatonin rhythm as a marker of circadian status. Diagram of a stylized plasma or saliva melatonin or urinary 6-sulphatoxymelatonin rhythm with the characteristics that have been used to define circadian status. Each body fluid has advantages and disadvantages from a practical point of view. Plasma is the most precise, with short interval sampling, saliva and aMT6s are the most useful for field studies. For long term monitoring of circadian status urinary aMT6s is well-tolerated. From Arendt (194), by permission.