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. 2019 Jul 16;10:1638. doi: 10.3389/fimmu.2019.01638

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Copyright © 2019 Hid Cadena, Reitsema, Huitema, van Sleen, van der Geest, Heeringa, Boots, Abdulahad and Brouwer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Frequencies of immune checkpoint molecule expressing circulating monocytes of GCA patients and HCs. Frequencies of peripheral monocytes expressing CD80/86 and VISTA (plotted on left y-axis) were decreased in GCA patients (n = 30) compared with HCs (n = 18). Frequencies of peripheral monocytes expressing PD-1 ligands (PD-L1 and PD-L2) (plotted on right y-axis) were comparable between GCA patients and HCs. The red horizontal lines represent the median. Significant differences by the Mann-Whitney U-test are indicated: ^*P < 0.05, ^**P < 0.01, ns, non-significant.