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. 2019 Jul 18;11:6691–6702. doi: 10.2147/CMAR.S200627

Figure 2.

Figure 2

IL-37 recruits dendritic cells (DCs) by stimulating tumor cell-derived CCL chemokine production in hepatocellular carcinoma (HCC). (A) Stable IL-37 expression in Hep3B cells was confirmed by Western blotting. (B) The levels of IL-37 secreted by Hep3B/LV-IL37 cells and Hep3B/LV-NC cells. Data presented are from three separate experiments. (C) Numbers of DCs attracted by DMEM alone, DMEM with recombinant IL-37, supernatant of Hep3B/LV-NC and supernatant of Hep3B/LV-IL37, respectively. Data from three separate experiments are presented. (D) The expression levels of mRNA encoding CCL chemokines in Hep3B/LV-IL37 cells compared to Hep3B/LV-NC cells. Data presented are from three separate experiments. **P<0.01, NS: not significant.