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. 2019 Jul 18;11:6691–6702. doi: 10.2147/CMAR.S200627

Figure 3.

Figure 3

IL-37 indirectly enhances the ability of dendritic cedendritic cells (DCs) to induce anti-tumor immune response. DCs were cultured in DMEM alone, DMEM with recombinant IL-37, supernatant of Hep3B/LV-NC and supernatant of Hep3B/LV-IL37, respectively. (A and B) The expression levels of major histocompatibility class (MHC) class I, MHC class II, CD80, CD86 and CD40 on DCs. Data presented are from three separate experiments. (C) The expression levels of the mRNA encoding CXCL9 and CXCL10 in DCs. Data presented are from three separate experiments. (D and E) The levels of IL-2, IL-6, IL-10, IL-12, IL-12p70, CXCL10, TNF-α, interferon-α (IFN-α) and IFN-γ secreted by DCs. Data presented are from three separate experiments. *P<0.05, **P<0.01, ***P<0.001, NS: not significant.