Skip to main content
. 2019 Jul 18;11:6691–6702. doi: 10.2147/CMAR.S200627

Figure 5.

Figure 5

IL-37 indirectly promotes dendritic cell (DC) recruitment and anti-tumor function in vivo. (A) Stable IL-37 expression in Hepa 1–6 cells was confirmed by Western blotting. (B) The levels of IL-37 secreted by Hepa 1–6/LV-IL37 cells and Hepa 1–6/LV-NC cells were detected through ELISA. Data presented are from three separate experiments. (C) MTS assays indicated that overexpression of IL-37 did not significantly affect ex vivo Hepa 1–6 cell proliferation. Data presented are from three separate experiments. (D) Photographs of dissected tumors from C57BL/6 mice in the Hepa 1–6/LV-IL37 group and Hepa 1–6/LV-NC group. (E) Tumor growth curves of Hepa 1–6/LV-IL37 group and Hepa 1–6/LV-NC group. (F) The final tumor weights of Hepa 1–6/LV-IL37 group and Hepa 1–6/LV-NC group. (G–J) The expression of IL-37, the density of CD11c+DCs, CD4+T cells and CD8+T cells infiltration in murine tumors (original magnification: ×400). Data presented are from six separate experiments. **P<0.01, ***P<0.001, NS: not significant.